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1825-
|
Lindane, also known as hexachlorocyclohexane (HCH), is synthesized by Michael Faraday6
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| |
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1853-
|
Stanislao Cannizzaro obtains benzyl alcohol and benzoic acid from the treatment
of benzaldehyde with potash7
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|
1858-
|
Pyrethrum, the first of the pyrethroid insecticides, derived from the Dalmation
Chrysanthemum [C. cinerariaefolium], was first used in the US8
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| |
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1932-
|
German chemist Willy Lange and his graduate student, Gerde von Krueger, first described
the nervous system effects of organophosphates (the family of compounds which includes
malathion and certain nerve gases) in mammals9
|
| |
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1942-
|
Lindane's insecticidal properties are discovered6
|
| |
|
1951-
|
Malathion is first registered for insecticidal use in the US9
|
| |
|
1974-
|
The avermectins, including ivermectin are discovered when isolated from a naturally
occurring soil organism found in a routine soil sample in Japan10
|
| |
|
1981-
|
Ivermectin is approved by the US FDA to control certain parasites in domestic mammals10
|
| |
|
1987-
|
Ivermectin receives formal regulatory clearance for use in humans by the French
Directorate of Pharmacy and Drugs. It is indicated to control onchocerciasis (river
blindness), and distribution begins through the Mectizan Donation Program in equatorial
Africa10,11
|
| |
|
2005-
|
Topaz Pharmaceuticals begins research and development on a novel topical form of
ivermectin. This formulation is currently under clinical investigation as a potential
therapy to treat head lice. Learn more about ivermectin.
|
| |
|
2007-
|
Over 530 million doses of ivermectin have been given for the prevention of river
blindness12
|